Emergency preparedness and response are critical for global health security in an era of increasing public health threats. From pandemics to natural disasters, African nations face complex health emergencies requiring swift and coordinated responses. Recognizing the urgency of strengthening health security, Dr. Chikwe Ihekweazu, Acting WHO Regional Director for Africa, and Dr. Abdou Salam, WHO Regional Emergency Director, conducted a high-level mission to Ethiopia from March 13 to 14, 2025.