The Second International Conference on PEN-Plus in Africa (ICPPA 2025) was held from 8 to 10 July 2025 in Abuja, Nigeria, following the successful inaugural event in April 2024 in Dar es Salaam, Tanzania. Under the theme "Advancing the implementation of PEN-Plus for severe NCDs in Africa: Technical innovations, operational insights, and scalable solutions," the conference brought together over 450 participants (over 150 in-person and 300 online), including government representatives, technical experts, implementing partners, civil society, and people living with NCDs.

This report provides a comprehensive overview of the major achievements and activities of the Health Promotion, Disease Prevention and Control(DPC) Cluster in a difficult year.

This guide to managing public health programmes in Africa is timely. It comes when the region is not only re-organizing, but re-thinking how to ensure that we reach the targets of the Sustainable Development Goals in an increasingly fragmented and difficult context. But with threats come opportunities, and as the region changes focus to face this new world, this guide will equip new leaders in public health with the tools they require to make their mark on health development and security regionally and at country level.

Leishmaniasis is a neglected tropical disease that predominantly affects impoverished populations. It remains a significant health issue in four eco-epidemiological regions: the Americas, East Africa, North Africa, and West Asia and Southeast Asia.

This is the third progress report produced by the UCN Cluster of the World Health Organization (WHO) Regional Office for Africa.

In 2023, the World Health Organization Regional Office for Africa adopted a new strategy for Ending Disease in Africa (ENDISA) 2023-2030.

PEN-Plus contributes to reducing premature mortality from severe NCDs by providing integrated care and services among Africa's poorest children and young adults.

Rheumatic heart disease (RHD) is a significant cause of heart failure globally, with over 40.5 million people affected worldwide in 2019. Sub-Saharan Africa accounts for 23% of RHD cases worldwide, with an estimated prevalence rate of 10.31 cases per 1000 people.

Diabetes is a chronic disease that occurs when either the pancreas does not produce enough insulin, or when the body cannot effectively use the insulin it produces.