African Vaccine Regulatory Forum (AVAREF) was established by WHO in 2006 as a network of National Regulatory Authorities (NRAs) and Ethics Committees (ECs) of African countries providing a platform for building regulatory capacity and promoting harmonization of practices in support of oversight of clinical trials in the region. AVAREF has since played a crucial role in the successful development of several vaccines, notably the meningococcal A conjugate vaccine, whose licensure and rollout has dramatically reduced epidemics of meningococcal A meningitis. The capacity of AVAREF has now been broadened beyond vaccines and includes medicines.
The Zambian government has committed itself to ending cholera by the year 2025 through the validation of the national multi-sectoral cholera elimination plan for the period 2019
