Annual progress report of the Mwele Malecela Mentorship Programme (MMM) for Women in Neglected Tropical Diseases, covering the period from 1 January to 31 December 2025. The report presents the milestones, activities and learnings of the programme, led by the WHO Regional Office for Africa through the Expanded Special Project for Elimination of Neglected Tropical Diseases (ESPEN), in collaboration with The END Fund and the American Society of Tropical Medicine and Hygiene (ASTMH).